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Athletic Recovery and Oxidative Stress from Exercise Intense physical exercise generates substantial ROS production, with muscle tissue experiencing oxidative stress proportional to exercise intensity

Exercise training has also been demonstrated to have anti-apoptotic effects by increasing IGF-1, IGF-1 receptor, p-PI3K, Bcl-2, HSP 72, and p-AKT, and decreasing Bid, t-Bid, Bad, Bak, Bax, TNF, and FADD [131]

Infectious pathogens thought to promote the development of ME/CFS are summarised in Figure 4

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