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The purified homogeneous polysaccharide from the Sijunzi Decoction, S-3-1, has been shown to modulate essential gut microbiota, including Lactobacillus , Pediococcus , Streptococcus , Bacteroides , Enterococcus , Clostridium , and Dorea

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In a prospective study of T2DM patients, six months of liraglutide therapy improved diastolic function and reduced left ventricular mass index [44], while additional echocardiographic studies have reported improvements in global longitudinal strain and left ventricular mass with GLP-1 receptor agonists [45]