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Urinary urgency & retention (alpha-mediated effects on the urinary bladder) Piloerection Pharmacokinetics: given orally midodrine is converted the active metabolite (desglymidorine) by removal of a side group (deglycation) by enzymes present in many body tissues, including the liver

This can occur during physiological processes such as luminal antigen sampling by immune cells and M cells to detect the presence of foreign compounds and stimulate an inflammatory response if necessary (Mainous et al

Bush Hoffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK

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