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This treatment is not for anyone who has chronic kidney disease or whose creatinine levels exceed 2.5mg/dl

The documentation timeline is the deciding factor, not the hemoglobin value

Mol Ther Nucleic Acids 36(2):102543 Acknowledgements The authors thank all participants who were included in this study

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It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number