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Twenty-two states currently have MLTSS programs for some or all of their populations, two more states will begin implementation in 2017, and several more programs are in the design stage (Center for Health Care Strategies, forthcoming)
Key mechanisms include: Stimulation of collagen and elastin synthesis in fibroblasts Activation of lysyl oxidase for collagen cross-linking Enhanced production of glycosaminoglycans and decorin Modulation of metalloproteinase activity for controlled matrix breakdown The copper ion serves as an essential cofactor for enzymes involved in collagen synthesis and provides antioxidant protection through superoxide dismutase activation
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IRE1 Implications in endoplasmic reticulum stress-mediated development and pathogenesis of autoimmune diseases
[PubMed: 40865172] Abdalla Ahmed MA, Ssemmondo E, Mark-Wagstaff C, Sathyapalan T
