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GLP-1 is thought to mediate this through inhibiting Rho GTPase in the cyclic adenosine 3,5-monophosphate (cAMP)/protein kinase A (PKA) pathway [25]

This natural ingredient is widely regarded as a safe complement to medically prescribed pigment correctors, offering additional advantages such as photoprotection against UV, HEV blue light, and IR light

Five biological mechanisms account for the vast majority of lip discoloration cases: cumulative UV exposure, tobacco-induced melanocyte activation, post-inflammatory hyperpigmentation following irritation or injury, hormonal melasma-type pigmentation, and allergic reactions to cosmetic products

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Most patients notice a significant reduction in appetite within the first few days of treatment