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For example, as a transcriptional coactivator, peroxisome proliferator-activated receptor coactivator 1 (PGC1) has been reported to be downregulated in TC cells, thereby inhibiting oxidative phosphorylation and inducing a glycolytic phenotype

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Though once thought unable to cross cell membranes, our clinical results with IV NAD+ injections suggest otherwise

doi: 10.1038/nature05859 30 StockwellBRFriedmann AngeliJPBayirHBushAIConradMDixonSJet al