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The enzyme doesnt wait for the hormone to circulate it cleaves GLP-1 in the gut wall and portal vein on the way to the heart

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Although this review has covered the activity of many important hormones involved in promoting metabolic homeostasis, many other molecules and hormones such as gastrin and noradrenaline are involved in this process, 40 and their role in promoting metabolic homeostasis in healthy individuals and how their activity could become dysfunctional and promote pathology has not been discussed

GLP-1 receptor agonists, which are known to elicit weight reduction in patients, are recommended as the second-line therapy for type 2 diabetes