Adjusting the focus on -secretase inhibition
CuPT inhibits cancer cell growth by targeting active sites of 19S DUBs (UCHL5 and USP14), leading to accumulation of both total and K48-linked ubiquitinated proteins (e.g., CDKN1A, CDKN1B, BAX, and NFKBIA) and GFPu (a surrogate proteasome substrate) (Liu et al., 2014b)
Glucosamine Sulfate
Once glutathione hits the bloodstream, its carried throughout the entire body, reaching all of the important organs such as the brain, heart, lungs, and muscle tissue
Additionally, our molecular experiments confirmed that chemotherapy drugs increase the expression levels of intracellular GSH and antioxidant enzymes, leading to chemotherapy resistance during neoadjuvant chemotherapy