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For instance, it is believed that epithelial cells can reprogram neighbouring stromal fibroblasts to increase the fibroblasts secretion of pyruvate and lactate, so that the epithelial cells may take up these energy-rich metabolites themselves (Pavlides et al, 2009)

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Importantly, the reduction in LBM was modest relative to the overall BW loss, suggesting that GLP-1 RAs favor selective adipose tissue reduction over loss of lean tissue

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