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However, concerns exist regarding the impact of GLP-1 RAs on lean mass, particularly with respect to true skeletal muscle mass

This interaction activates the Akt/mTOR pathway , which is responsible for: Stimulating muscle protein synthesis Promoting cell proliferation and differentiation Enhancing collagen and connective tissue formation Supporting cellular repair and regeneration A review 3 explains that this biochemical process makes IGF-1 LR3 a promising tool for maintaining or regaining muscle mass, particularly during recovery or rehabilitation periods