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In a study of adipose mass, growth therapy treatment for 26 weeks resulted in: Subcutaneous fat mass decreased by 13% Intra-abdominal fat mass reduced by 30% Lean body mass increased by 3-11% Aerobic function improved by 11-19% Muscle strength increased by 7-19% These changes continued during one year of treatment resulting in a 22% reduction in overall fat mass and a 61% reduction in belly fat

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But the preclinical evidence is striking enough that major research institutions are investing significant resources to investigate further

Clinically, deficiency result in various pathologies, most notably, beriberi, a cardiomyopathy with edema and lactic acidosis, and WernickeKorsakoff syndrome or Wernickes encephalopathy