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Pancreatitis was rare in the SURPASS and SURMOUNT clinical trials involving over 6,000 participants, with incidence rates comparable to control groups and not significantly elevated compared to placebo

Notably, a recent study introduced a predictive model with strong performance (concordance index [C-index] = 0.827, 95% confidence interval [CI] = 0.7720.882) for early detection of ED in subjects with type 2 diabetes (T2D), incorporating variables such as diabetes duration, carotid intima-media thickness (CIMT), and low-density lipoprotein cholesterol (LDL-C) levels [15]

This enables simultaneous investigation of diverse disease mechanisms and reconstruction of complex pathophysiological models