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Spectrum raw files were extracted into MS1, MS2, and MS3 (For TMT experiments) files using RawConverter ( The tandem mass spectra were searched against the UniProt human protein database, including isoforms (downloaded on 01-01-2014), and matched to sequences using the ProLuCID/SEQUEST algorithm (ProLuCID version 3.1) with 5 ppm peptide mass tolerance for precursor ions and 600 ppm for fragment ions

References 1 AgarwalS.RaoA

Hyperthyroidism can also lead to increased insulin resistance

Its unique beta subunit drives targeted activity, while downstream signaling via PKA and PKC pathways enhances steroidogenesis and cellular differentiation

Most studies concerning the effects of IGF-1 derivatives have been carried out in non-human animal models or cell culture studies Insulin Like Growth Factor Receptor Interactions IGF-1 binds to at least two cell surface receptors: IGF-1R and the insulin receptor