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2 Diet can affect the gut microbiota Gut microbiota refers to the entire microbial ecosystem that inhabits the gastrointestinal tract of mammals, including bacteria, fungi, viruses, and protozoa (17)

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The STEP-HFpEF trial was designed to evaluate the effects of treatment on symptoms and physical limitations, exercise function and inflammation, along with body weight, and was, therefore, not powered to assess clinical endpoints such as HF hospitalizations

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