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[ref] Carnitine: The study on mice showing that carnitine transport is essential for GLP-1 RA effectiveness indicates that low carnitine levels may impair weight loss.[ref] More studies are needed, but it may be that adding supplemental carnitine could help, especially if you have genetic variants related to lower carnitine levels
Exercise The impact of exercise on weight loss, particularly on a low-calorie diet can be impressive
The regain problem The main theory for why the majority of patients regain weight so rapidly when they stop taking medication is because the regions of the brain relating to appetite are still dysregulated, priming the person to overconsume
The medication is not being prescribed for weight reduction or weight maintenance
This concept by no means is incompatible with the finding that inhibition of GCGR signalling also results in alpha cell proliferation but we emphasise that the latter effect operates on a much longer time scale than the acute effect we now describe (days/weeks rather than minutes/hours)
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