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Neither medication substantially alters the pharmacokinetics of the other, making them safe to dose independently under medical supervision

These medications can support appetite control and weight loss as part of a provider-guided plan

For increased patient safety in APAP consumption, the FDA has worked to mitigate APAP hepatotoxicity by legislating regulations to limit prescription combination drug products to have no more than 325 mg of APAP per dosage unit and have urged healthcare providers to cease prescribing combination drug products with more than 325 mg of APAP per tablet

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In the renal impairment study, this was in part owing to disruption by the COVID-19 pandemic, with temporary closure of the two study centres