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Since co-treatment of UK-5099 and JMF4073 depleted dTTP pool and suppressed the growth of T315-Bcr-Abl-32D cells, we proposed that reducing GSH biosynthesis induces not only oxidative stress but also replication stress in tumor cells, which demands the synthesis of dTTP and dCTP for survival

Abbreviations -ECS -Glutamylcysteine synthetase ABA Abscisic acid APX Ascorbate peroxidase AsA Ascorbate CAT Catalase Cys Cysteine DHAR Dehydroxyascorbate reductase Glu Glutamine Gly I Glyoxalase I (Lactoylglutathione lyase) Gly II Glyoxalase II (Hydroxyacylglutathione hydrolase) GPX Glutathione peroxidase GR Glutathione reductase GSH Glutathione GSHS Glutathione synthase GSNO S -Nitrosoglutathione GSSG Glutathione disulfide GST Glutathione S -transferase JA Jasmonic acid MAP Mitogen activated protein MDA Malondialdehyde MG Methylglyoxal NADPH Nicotinamide adenine dinucleotide phosphate NO Nitric oxide PC Phytochelatin PCS Phytochelatin synthase POD Peroxidase ROS Reactive oxygen species SA Salicylic acid SLG S -d-Lactoylglutathione SOD Superoxide dismutase Compliance with ethical standards Conflict of interest The authors declare no conflicts of interest

pylori supernatant or Hp-KS-1 supernatant was incubated with gastric cells for 12 h at a final dilution of 1:35 and divided into H

The running buffer (PBST, 25 C) was degassed prior to use

Singh A, Jahan N, Radhakrishnan G, Banerjee BD