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Regarding the latter resolution, this paper introduced the use of GLP-1RAsa drug class traditionally used in the treatment and management of T2DM and obesityas a potential avenue for the treatment of neurodegenerative diseases and neuropathologic conditions alike due to the drugs extensively cited neuroprotective effects

In a meta-analysis of the AMPLITUDE-O trial, HARMONY trial, and FLOW trial the risk of major adverse cardiovascular events with GLP-1 RA therapy was similar in those receiving and not receiving an SGLT2 inhibitor at baseline (HR 0.77

This is due to both limited coverage and limited supply

& Zolla, L