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They are not as bioavailable because they become metabolized in passing through the stomach

Less common side effects include diarrhea and fatigue

Ponikowski, P., Kirwan, B

So instead of having a clear run through, magnesium is often: queueing behind other minerals slowed down by high-fibre meals limited by how fast those shared tunnels can move minerals through Even with better-absorbed forms like magnesium glycinate, stress, alcohol, medications, slow stomach acid, gut irritation, pH balance, and the tight controls on magnesium blood level allowance affect magnesium absorption and availability

Alpha and beta hydroxy acids Exfoliating acids like glycolic acid, salicylic acid, and lactic acid can interfere with copper peptide efficacy