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This hormone was first identified in the 1990s and pharmaceutical drugs were developed shortly after to mimic its effects

The larger the dose, the more extreme the effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Tobias GC, Gomes JLP, Fernandes LG, Voltarelli VA, de Almeida NR, Jannig PR, de Souza RWA, Negro CE, Oliveira EM, Chammas R, Alves CRR, Brum PC

Semaglutide offers flexibility with both a once-weekly injectable option and a once-daily oral tablet

A 2020 pharmacokinetic study published in Clinical Pharmacokinetics found that oral semaglutide reduced the Cmax of co-administered levothyroxine by approximately 33% in healthy volunteers