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The mutation of GIPR Glu 354 to Gln increases GIP affinity, enhances the agonist residence time by 25%, increases cAMP activity, and facilitates the rate of internalization by 2.12.3-fold

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Jimenez J, Washington MA, Resnick JL, Nischal KK, Fedorchak MV (2021) A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability