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Chief among them is the induction of hypoglycemia, which can destabilize neuronal homeostasis and increase cortical excitabilityan established precursor of cortical spreading depression, particularly in migraine with aura

10.1038/ng.686 92 StevensC

Weight loss of this magnitude has cascading health benefits

Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin

Using rodent models of obesity and metabolic dysfunction, the research group demonstrated that the triple-agonist approach produced meaningful reductions in body weight and improved glycaemic parameters compared to both placebo and comparator compounds targeting fewer receptors