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Controlled levels of ROS enhance FSH signaling [46], whereas redox imbalance or mitochondrial damage can activate intrinsic apoptotic pathways [34, 35], leading to granulosa cell dysfunction or follicular atresia
By testing all of these, they identified one location in the peptide where putting a staple not only improves the molecules stability and helps it get into cells, but also makes it bind even more tightly to Mcl-1
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