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In hyperuricemia, uric acid is supersaturated in urine and forms uric acid crystals, which are transported to lysosomes by the endocytosis of renal tubular epithelial cells, destroying the lysosomal membrane and causing lysosomal rupture, in turn, resulting in renal inflammation 20

Additive gastrointestinal effects : Tirzepatide commonly causes nausea, vomiting, diarrhea, and constipation, particularly during dose escalation

It controls oil production and helps smooth fine lines, making it ideal for all skin types

Besides, NRF2 acts as a vital transcription factor that regulates bone homeostasis 27

B12 plays a role in immune function, potentially helping athletes stay healthy and maintain their training schedules