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Addressing excess weight around the midsection isnt just about vanity, it can pose a health risk: Associated metabolic complications can include fatty liver disease and hypertension, the latter of which, says Reena Bose, MD, an internal medicine and obesity medicine specialist at Cleveland Clinic, increases almost 30 percent with even a 10-pound weight gain

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The most notable disappointment was CagriSema, an experimental obesity drug

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