doi: 10.3389/ftox.2025.1655489 Received 28 June 2025 Accepted 03 October 2025 Published 20 October 2025 Volume 7 - 2025 Edited by Maria Glymenaki, Imperial College London, United Kingdom Reviewed by I-Chen Li, Grape King Bio Ltd, Taiwan Nand Kumar Kadhyap, Dr C V Raman University Faculty of Engineering, India Alejandre-Rosas J
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ROS acts as a central hub connecting ferroptosis to PCa pathogenesis, amplified by inflammatory signals and redox-sensitive transcription factors (e.g., Nrf2, HIF-1) that either directly enhance oxidative stress or indirectly modulate ferroptosis susceptibility [Figure 2A]