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doi: 10.1038/s41392-024-01772-w 36 KangYPMockabee-MaciasAJiangCFalzoneAPrieto-FariguaNStoneEet al

Constipation and bladder pressure Constipation is one of the most common semaglutide side effects , affecting roughly 12-20% of users depending on the dose

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However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols

Clinical Evidence on Weight Regain Rates and Timeline The SUSTAIN-7 trial and real-world data consistently show that weight rebound begins within weeks of stopping semaglutide and accelerates over months