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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

A number of satiety signals that are released from the intestine include cholecystokinin (CCK), pancreatic polypeptide (PP), peptide-YY (PYY), oxyntomodulin, enterostatin, and glucagon -like peptide-1 (GLP-1) [5-10]

Lotz-Havla AS, Wei KJ, Schiergens KA, Brunet T, Kohlhase J, Regenauer-Vandewiele S, Maier EM

In most cases, treatment changes meant patients injections had been suspended and replaced with B12 tablets and nutritional advice provided

This feature could make it more accessible to individuals with specific health concernsthough medical guidance is always essential