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Exendin-4 enhances the binding of heat shock factor 1 to the promoter of heat shock protein (HSP) genes through SIRT1-mediated deacetylation, which then increased the expression of molecular chaperones HSP70 and HSP40 to alleviate lipid-induced hepatic ER stress

Epub 2016 Aug 20

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways

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The lack of commonly available antibodies to detect GIPR is another limitation that hampers immunohistochemical analysis of potentially relevant drug targets in the brain