One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors
This dual GIP and GLP-1 receptor agonist, licensed in the UK for type 2 diabetes and weight management, commonly causes gastrointestinal side effects such as nausea, diarrhoea, and constipation due to its effects on gut motility
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Do not take any medicine on your own for managing diarrhoea
The announcement comes as digital health companies increase their presence in the blockbuster market for GLP-1s to treat obesity, diabetes and other chronic conditions a space that could be worth roughly $100 billion by the end of the decade, according to some analysts
