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This process has been best studied in the BRAF context, where the activation BRAF V600E causes unphysiologically high downstream MAPK signaling leading to cell stress and CDKN2A-mediated G1 cell cycle arrest 52

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Wild-type mice with femoral fractures show increased CGRP serum levels after injury, and alpha-CGRP mRNA expression is exclusively induced in callus tissue but not in other organs, suggesting a targeted skeletal response

Because of that, physicians have relied on workaround medications like topiramate, bupropion, and naltrexone