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Nguyen, M.S., Patrick M
Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, et al
The results with semaglutide alone are encouraging and suggest a potential new treatment option for a group of patients who previously had very few. The Phase II trial followed about 700 adults with biopsy-confirmed MASH and moderate to advanced liver scarring, including participants who had already developed early cirrhosis
The agency permits some unapproved drugs to be marketed if they are relied on by health care professionals to treat serious medical conditions when there is no FDA-approved drug to treat the condition or there is insufficient supply of FDA-approved drugs. Given these complexities, ideal patient candidates for Retatrutide include individuals with significant obesity, persistent insulin resistance, and metabolic syndrome who have not adequately responded to other medically supervised weight-loss strategies and who clearly understand the investigational status of the medication
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