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Acute gentamicin ototoxicity paradigm: Under anesthesia, animals are administered a single intratympanic injection of gentamicin (400 mg/ml) of a volume of 50 L

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USADA has specifically noted that no safe dose has been established in humans

Second, the published research is dominated by in-vitro and animal-model studies, where doses are expressed in laboratory units (micromolar, micrograms per kilogram of bodyweight in animals) that do not translate to a human personal-use figure

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