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As a small or mid-sized business leader, youre no stranger to managing costs and making tough decisions for the long-term success of your company

eCollection 1002018 Apr

Indeed endocannabinoid signaling through CB1R regulates the activity of dopamine (DA) neurons in the VTA [52], which projects to the nucleus accumbens, a key brain reward region activated by addictive drugs including THC [53, 54]

An additional and important caution applies if either agent is used alongside insulin or a sulfonylurea: retatrutide's glucose-lowering activity may increase the risk of hypoglycaemia in this context, and dose review of any existing antidiabetic medicines would be essential before combining treatments

Contributors from my own department are mentioned in the Acknowledgment