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That made them a logical group of drugs to study in breast cancer populations, especially because preclinical work has suggested possible anticancer effects and because weight reduction itself may influence long-term outcomes

To date, most of the in vitro and in vivo evidence for the potential of MC drugs in fibroblast-driven diseases have been conducted using the natural agonist MSH, but the time is ripe to move forward into testing improved synthetic analogues and small molecules with higher pharmacokinetic and pharmacodynamic profiles to provide hopes for the effective management of countless diseases with high needs involving dysregulated fibroblasts