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Several classes of medications may interact with semaglutide, including: Anticonvulsants Antidepressants Antipsychotics Beta-blockers HIV medications Corticosteroids Diuretics Hormones Additionally, caution is warranted when combining semaglutide with insulin, as this may elevate the risk of hypoglycemia

For Medicare members seeking the CV indication under J-1370, confirm that concurrent statin therapy or documented statin intolerance is part of your clinical record

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Written by Mace Scott, MD Founder and Medical Director at Chronos Body Health & Wellness Focus: medical weight loss, hormone optimization, wellness medicine, aesthetics Updated: May 2026